[2007-04-14] Radioprotective Potential of Plants and Herbs against the Effects of Ionizing Radiation

Abstract

Ionizing radiations produce deleterious effects in the living organisms and the rapid technological advancement has increased human exposure to ionizing radiations enormously. There is a need to protect humans against such effects of ionizing radiation. Attempts to protect against the deleterious effects of ionizing radiations by pharmacological intervention were made as early as 1949 and efforts are continued to search radioprotectors, which may be of great help for human application. This review mainly dwells on the radioprotective potential of plant and herbal extracts. The results obtained from in vitro and in vivo studies indicate that several botanicals such as Gingko bilobaCentella asiaticaHippophae rhamnoidesOcimum sanctumPanax ginsengPodophyllum hexandrumAmaranthus paniculatusEmblica officinalisPhyllanthus amarusPiper longumTinospora cordifoilaMentha arvensisMentha piperitaSyzygium cuminiZingiber officinaleAgeratum conyzoidesAegle marmelos and Aphanamixis polystachya protect against radiation-induced lethality, lipid peroxidation and DNA damage. The fractionation-guided evaluation may help to develop new radioprotectors of desired activities.

Keywords: radioprotection, antioxidant, survival, micronuclei

Source: Radioprotective Potential of Plants and Herbs against the Effects of Ionizing Radiation

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